With a month of all-new medical mysteries and guest star David Morse, HOUSE opens November Sweeps in a big way when a 600-pound man, George Hagel (guest star Pruitt Taylor Vince), is admitted to the hospital after he is found in his apartment in a coma. George believes his problems are unrelated to his weight and wants the team to come up with another explanation, but his size makes testing difficult. It’s not until House has a physical altercation with his patient that the case becomes clear. Meanwhile, after House is arrested, Officer Michael Tritter (guest star Morse) puts the squeeze on the good doctor, searching his home for evidence of drug abuse and questioning Wilson about House’s relationship with Vicodin in the “Que Sera Sera” episode airing Tuesday, Nov. 7 (9:00-10:00 PM ET/PT).

The next all-new November Sweeps HOUSE call, “Son of Coma Guy” (Tuesday, Nov. 14, 9:00-10:00 PM ET/PT), features guest star John Larroquette as Gabe, a man who has been in a coma for 10 years. Noticing something “off” about Gabe’s visiting son, Kyle, House conducts a mini-experiment that leaves the boy unconscious. When symptoms point to a possible genetic condition, House and his team must glean a family history from Kyle’s only living relative – his comatose father. Meanwhile, Wilson confronts House about stealing his prescription pad, and Tritter (guest star Morse) questions Cameron, Foreman and Chase, dividing the team and revealing where their individual loyalties lie.

Patrick Fugit (“Almost Famous”) guest-stars in the Tuesday, Nov. 21 (9:00-10:00 PM ET/PT) outing of HOUSE, titled “Whac-A-Mole,” as Princeton Plainsboro’s newest patient and heart attack victim, 18-year-old Jack. Barely an adult himself, Jack has been the parent to his younger brother and sister since their parents died. After a brief perusal of Jack’s file, House thinks he’s got the diagnosis, seals it in an envelope and turns the process into a game, challenging Cameron, Foreman and Chase to figure it out on their own. When Jack is given an option that would lead to a possible reprieve from his worsening illness, he’s faced with a decision that could break up his little family forever. Meanwhile, in an attempt to extract a confession, Tritter (guest star Morse) makes it almost impossible for Wilson to practice medicine, driving a friendship-ruining wedge between House and Wilson.

In “Finding Judas” (Tuesday, Nov. 28, 9:00-10:00 PM ET/PT), the final November episode of HOUSE, the team takes on the case of a young girl admitted with pancreatitis. When her divorced parents won’t agree on how to proceed with her treatment, House takes the parents to court to have a judge make the decision for them. Meanwhile, Detective Tritter’s (guest star Morse) investigation intensifies after he offers Foreman a deal to come clean about House’s drug use.