Originally aired November 1, 2005.

Dr. Sebastian Charles: "Look, I know I have a way about me. I know I piss a lot of people off and a whole lot more I just annoy. But, you're the first person that I've ever met who I think is actually annoyed by what I do. Do you think I'm not saving any lives or is that a bad thing?"
House: "Right now, I'm just trying to save your life."
Dr. Sebastian Charles: "Or do you just have a problem with hope? You know, the difference between our jobs is not numbers or styles. It's that I know I'm gonna fail. Even if I save a million people there's gonna be another million. You couldn't handle that. I think you resent anyone who can."
House: "Can't we just agree that you're incredibly annoying? Take the pills or I let you die, do an autopsy, call my own press conference and make sure the world knows that you didn't die of TB. Corporate sponsors will be disappointed, but they'll find another disease."
Dr. Sebastian Charles: "Why would you do that?"
House: "Because I'm just a mean son of a bitc*."