Originally aired December 28, 2004.

House: Husband described her as being unusually irritable recently.
Cameron: And?
House: I didn't realize it was possible for a woman to be "unusually" irritable.
Cameron: Nice try, but you're a misanthrope, not a misogynist.

Foreman: Why are you riding on me?
House: It's what I do. Has it gotten worse lately?
Foreman: Yeah. Seems to me.
House: Really? Well, that rules out the race thing. You were just as black last week.

Foreman: How come [House] doesn't ride you guys?
Chase: He's got a crush on you. He just doesn't know how to show it.

Foreman: Sleeping sickness from sex?
House: It's not without precedent.
Foreman: I'm pretty sure it is, unless you're talking about going to Africa and having sex with the tsetse fly.

House: (To Chase). You put the Queen on your money. You're British.

Cameron: You want me to ask a man whose wife is about to die if he's cheating on her?
House: No, I want you to be polite and let her die.

House: As long as you're trying to be good, you can do whatever you want.
Wilson: And as long as you're not trying, you can say whatever you want.
House: So between us, we can do whatever we want. We can rule the world!

Wilson: I love my wife.
House: You certainly love saying it. (Wilson laughs in an annoyed way). I'm sorry. I know you love your wife. You loved all your wives. Probably still do. In fact, you probably still love all the women you ever loved who weren’t your wives.