At one point, a representative from an association for sufferers of an inflammatory condition called vasculitis stood up and thanked the show for calling attention to the malady. While none of the patients of cranky, brilliant Dr. Gregory House (Hugh Laurie) ever wind up having vasculitis, House and his team of doctors (Omar Epps, Jennifer Morrison, Jesse Spencer) often mention it as a possible diagnosis while trying to solve medical puzzles each week.

"I made some smart(aleck) remark," recalls show creator David Shore, "and they continued to be grateful. They sent us a lovely little plaque and a lovely letter saying, "You are doing God's work,' which was the essence of my smart(aleck) remark.

"For me, it's great, just because he's so great," Morse said of working with Laurie.

"Any time you get to work with somebody - not just with his talent, but with his generosity," it's worth it, he said. "And I think I appreciate that more and more in my life, to work with people who aren't just generous, but generous with their talent."

Morse, a working actor for 35 years, named no names, but said some actors think "misbehaving is part of their genius... and I've gotten a little tired of that."

With a month of all-new medical mysteries and guest star David Morse, HOUSE opens November Sweeps in a big way when a 600-pound man, George Hagel (guest star Pruitt Taylor Vince), is admitted to the hospital after he is found in his apartment in a coma. George believes his problems are unrelated to his weight and wants the team to come up with another explanation, but his size makes testing difficult. It’s not until House has a physical altercation with his patient that the case becomes clear. Meanwhile, after House is arrested, Officer Michael Tritter (guest star Morse) puts the squeeze on the good doctor, searching his home for evidence of drug abuse and questioning Wilson about House’s relationship with Vicodin in the “Que Sera Sera” episode airing Tuesday, Nov. 7 (9:00-10:00 PM ET/PT).

The next all-new November Sweeps HOUSE call, “Son of Coma Guy” (Tuesday, Nov. 14, 9:00-10:00 PM ET/PT), features guest star John Larroquette as Gabe, a man who has been in a coma for 10 years. Noticing something “off” about Gabe’s visiting son, Kyle, House conducts a mini-experiment that leaves the boy unconscious. When symptoms point to a possible genetic condition, House and his team must glean a family history from Kyle’s only living relative – his comatose father. Meanwhile, Wilson confronts House about stealing his prescription pad, and Tritter (guest star Morse) questions Cameron, Foreman and Chase, dividing the team and revealing where their individual loyalties lie.

Patrick Fugit (“Almost Famous”) guest-stars in the Tuesday, Nov. 21 (9:00-10:00 PM ET/PT) outing of HOUSE, titled “Whac-A-Mole,” as Princeton Plainsboro’s newest patient and heart attack victim, 18-year-old Jack. Barely an adult himself, Jack has been the parent to his younger brother and sister since their parents died. After a brief perusal of Jack’s file, House thinks he’s got the diagnosis, seals it in an envelope and turns the process into a game, challenging Cameron, Foreman and Chase to figure it out on their own. When Jack is given an option that would lead to a possible reprieve from his worsening illness, he’s faced with a decision that could break up his little family forever. Meanwhile, in an attempt to extract a confession, Tritter (guest star Morse) makes it almost impossible for Wilson to practice medicine, driving a friendship-ruining wedge between House and Wilson.

In “Finding Judas” (Tuesday, Nov. 28, 9:00-10:00 PM ET/PT), the final November episode of HOUSE, the team takes on the case of a young girl admitted with pancreatitis. When her divorced parents won’t agree on how to proceed with her treatment, House takes the parents to court to have a judge make the decision for them. Meanwhile, Detective Tritter’s (guest star Morse) investigation intensifies after he offers Foreman a deal to come clean about House’s drug use.

BEST MALE VILLAIN: Michael Tritter (David Morse ...) on "House" (Fox). When this fine Fox drama returns -- chillingly enough -- Oct. 31, House will have more than disgruntled patients and a bum leg to worry about. Morse plays a cop who'll hound House over the course of six episodes -- he has suspicions about how the doc gets his supply of pills -- all because the cranky doc treated him rudely in the clinic. Tritter's all the more scary because of Morse's understated performance, and I have to wonder how the ferociously smart House will wriggle out of this predicament.

Script revolves around a female cop, surrounded by an ensemble cast. Light drama will contain procedural elements but also a healthy dose of humor.

Universal Domestic Television Distribution has sold hit drama series House to local broadcast stations in more than 80 percent of the country starting in fall 2008. The Golden Globe winner and critically acclaimed series will air on weekends in national syndication.

"He works really hard, he's got such a tough gig," Spencer says of his Golden Globe-winning colleague. "Not just the medical stuff – which he has to deliver rapid-fire – but the accent on top of that is such a tall order. And a very difficult character. If I tried to play this character he'd probably just end up looking like an a****** but Hugh somehow brings a comedic edge into it."

Finally, on October 28th, the doctor is in as "House" star Hugh Laurie toplines SNL. Hailed as one of the best actors on television, Laurie stars in the hit medical drama and has garnered critical accolades as well as a Golden Globe and Screen Actors Guild award and an Emmy nomination. A veteran of groundbreaking British television comedy ("A Bit of Fry and Laurie," "Black Adder," "Saturday Live" and "Jeeves and Wooster"), Laurie has also appeared in films including "Flight of the Phoenix," "Sense and Sensibility," "Peter's Friends" as well as the family hits "101 Dalmatians" and the "Stuart Little" films. Educated at Eton and Cambridge University in the U.K., Laurie was elected president of the venerable Footlights Revue, where he worked with frequent castmates Stephen Fry and Emma Thompson.